There is potential cross-sensitivity between silver sulfadiazine and other sulfonamides. Some of the reactions, which have been associated with sulfonamides, are as follows: blood dyscrasias including agranulocytosis, aplastic anemia, thrombocytopenia, leukopenia, and hemolytic anemia dermatologic and allergic reactions, including life-threatening cutaneous reactions gastrointestinal reactions hepatitis and hepatocellular necrosis CNS reactions and toxic nephrosis. Although few have been reported, it is possible that any adverse reaction associated with sulfonamides may occur. Silver sulfadiazine is not a carbonic anhydrase inhibitor and may be useful in situations where such agents are contraindicated.Ībsorption of silver sulfadiazine varies depending upon the percent of body surface area and the extent of the tissue damage. In case of overdose, contact your veterinarian immediately and follow directions on manufacturer's information.Results of In Vitro Testing with SILVADENE ® Cream 1% (silver sulfadiazine) Concentration of Silver Sulfadiazine Number of Sensitive Strains/Total Number of Strains Tested Genus & Species Concurrent use of proteolytic enzymes such as collagenase, papain, or sutilains is not recommended since heavy metal salts may inactivate the enzymes. InteractionsĬoncurrent use with cimetidine may increase the incidence of leukopenia. Silver sulfadiazine is FDA approved for use in horses and is a prescription drug restricted to use by or on the oral or written prescription of a licensed veterinarian.Ĭheck with the appropriate regulatory body concerning use in competition horses. Prolonged use may lead to liver impairment and may cause hemolytic anemia.Īnimals sensitive to other sulfonamides such as furosemide may be sensitive to silver sulfadiazine. Urinalyses may be required prior to and periodically during treatment to detect crystalluria and/or urinary calculi formation in horses with impaired renal function on long-term or high-dose therapy. Monitoring of blood count and serum sulfadiazine concentration may be necessary in cases of treatment of extensive burns. Use of silver sulfadiazine may create areas of dead skin, a burning sensation, red and raised rash on the body, and skin discoloration. Follow your veterinarian's instructions regarding use of this, or any medication. Calculator is for educational purposes only. Always check the label and literature provided with the medication about the form and concentration and DO NOT USE the calculator if the information differs. This medication may be available in forms and concentrations not noted in the above table. Even if your equine appears to feel better, the entire treatment plan should be completed to prevent relapse. Be certain to complete the prescription unless specifically directed by your veterinarian. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects.Extra-label use of drugs in treating animals is allowable only by licensed veterinarians within the context of a valid veterinarian-client-patient relationship, and does not include drug use in treating animals by the layman (except under the supervision of a licensed veterinarian).Federal law restricts this drug to use by or on the order of a licensed veterinarian.Dosage and Administration Silver Sulfadiazine The American Journal of Veterinary research reports that it may be a therapeutic option in the treatment of equine keratomycosis. Ongoing research also shows that silver sulfadiazine may be an effective treatment against common corneal fungal infections in horses. It is also helpful on other shallow, large area wounds such as abrasions. It prevents the growth of a wide array of bacteria, as well as yeast, on damaged skin. Silver sulfadiazine is used primarily as a topical burn cream on second and third degree burns in horses. Silver sulfadiazine is typically delivered in a 1% solution suspended in a water-soluble base. It acts on the cell membrane and cell wall. It is effective against many gram-positive and gram-negative organisms. Silver sulfadiazine is a broad-spectrum, synthetic antibacterial agent with a chemical structure that includes sulfur and nitrogen atoms.
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